AB0711 Natriuretic Peptide Levels and the Correlation of Oxidative Stress in Patients with Ankylosing Spondylitis

Background Recently, studies are focused on finding the relation between Natriuretric Peptide and the immune system. Objectives The aim of the present study is assessing the role of serum levels of natriuretic peptides and the correlation of oxidative stress in patients with ankylosing spondylitis Methods This study has been carried out in patients with ankylosing spondylitis (AS). 45 patients with AS and 20 healthy controls were enrolled. Serum levels of pro atrial natriuretic peptide (proANP), brain natriuretic peptide (BNP), N terminal pro C type natriuretic peptide (NTproCNP) who were from natriuretic peptide (NP) family and myeloperoxidase (MPO) activity, serum levels of total lipid hydroperoxides (LHP), neopterin, total oxidant status (TOS), total antioxidant status (TAOS), tumour necrosis factor alpha (TNF-α), advanced oxidation protein products (AOPP) and thiol levels were assayed. Results There was no significant difference in neopterin, TNF-α, TOS, TAOS, proANP and NTproCNP concentration between patients with AS and healthy controls. ESR, CRP, AOPP, MPO, LHP and BNP levels were significantly higher in patients with AS than in controls. Thiol, albumin levels were significantly lower in patients with AS than in controls. There was statistically significant difference between acut phase response markers, ESR and CRP levels of active group and inactive group. AOPP and MPO levels were significantly higher in active group than in inactive group and control group. LHP and thiol levels were statistically significant different in active and inactive group than in control group. NTproCNP, AOPP and LHP levels were significantly higher in patients who were active status than in remission status. Thiol, albumin levels were significantly lower in patients who were active status than in remission status. Serum AOPP levels correlated with BASDAI and BASFI scores, CRP and ESR levels in patients with AS. Conclusions These results indicate that serum AOPP and proANP levels may reflect clinical activity of disease and may be helpful for monitoring patients with AS. The higher levels of MPO activity showed us enhanced production of ROS by activated neutrophils play a role in the pathogenesis of AS patients. It is thought that NPs related to the oxidative stres in patients with AS and may play an important role of the pathogenesis. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.1064