AB0067 IL-17F Gene Polymorphism Correlated with Longer Disease Duration of Rheumatoid Arthritis Patients

Background Rheumatoid arthritis (RA) is an autoimmune disease that results in chronic systemic inflammatory disorder that may affect many tissues and organs but principally attacks synovial joints. Interleukin-17F (IL-17) is a proinflammatory cytokine and IL17 F gene is an excellent candidate for chronic inflammatory cytokine. Objectives To investigate the potential association between rheumatoid arthritis and IL17 F gene polymorphism. Methods We investigated the potential association between rheumatoid arthritis and IL17 F gene polymorphism. 185 RA patients and 50 healthy control subjects were used. We compare IL17 F gene polymorphism with disease activity score, DAS28, Tender joints, Swollen joints, CRP. Results The polymorphisms of the IL-17F gene were not correlated with susceptibility to RA patients. However, the IL-17F variant was associated with parameters of disease activity, such as number of tender joints, DAS-28-CRP. Moreover, our findings have shown that IL-17F gene polymorphism may be correlated with longer disease duration in patients with RA. Conclusions Our results showed the relationship between IL-17F gene polymorphisms and severity of RA. References Seiderer J, Elben I, Diegelmann J et al. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in activated Crohn's disease and analysis of the IL-17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis 2008;14:437–45. Ramsey CD, Lazarus R, Camargo CA Jr, Weiss ST, Celedo'n JC. Polymorphisms in the interleukin 17F gene (IL17F) and asthma. Genes Immun 2005;6:236–41 Paradowska A, Maśliński W, Grzybowska-Kowalczyk A, Łacki J. The function of interleukin 17 in the pathogenesis of rheumatoid arthritis. Arch Immunol Ther Exp 2007;55:1–6. Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 2003;14:155–74. A. Paradowska-Gorycka, E. Wojtecka-Lukasik, J. Trefler, B. Wojciechowska, J.K. Lacki, S. Maslinski. Association between IL-17F Gene Polymorphisms and Susceptibility to and Severity of Rheumatoid Arthritis (RA). Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5482