THU0323 Achievement of clinical remission in patients with juvenile idiopathic arthritis after a long-term (2–5 years) etanercept exposure: A national referral center’s experience. (preliminary report)

Background Published data on the achievement of clinical remission (CR) - which is the ultimate goal of drug efficacy- over a long period of Etanercept (ETN) therapy in JIA patients, are worldwide sparse and completely lacking from Greece. Objectives To record the achievement of CR in JIA patients under ETN over a period of 2-5yrs and investigate predictors of CR. Methods Data from the 10-year Registry of our Pediatric Referral Center were retrieved. Patients previously resistant to conventional regimen and with a ≥2-year drug exposure were enrolled in the study. The annual impact of ETN on the disease course was assessed by the application of: a) American College of Rheumatology pediatric criteria (ACRpedi), b) the pre- and post-treatment disease activity score (Juvenile Arthritis Disease Activity Score [JADAS71]) and c) Wallace’s criteria for CR. Results 41pts (F: M 32:9) were enrolled in the study. Their median age at the time of the ETN dose was 10.6 yrs and their disease course was mainly polyarthritis (32/41). The median disease duration prior to study entry was 4.17 years. One of the pts received ETN for 2 different periods, 24 and 48 mo respectively, thus the annual number of ETN receivers were 42/42/29/20 and 13 from Year 1 to 5, respectively. The annual scores of ACRpedi 30/50/70/90/100 and the number of CR achievers are shown in Table 1. JADAS0 (baseline) did not correlate well with the subsequent achievement of CR. However, JADAS1 (1st year post-treatment) had a significant correlation with CR2 (2nd year post-treatment, p=0.002, ROC/AUC 0.81) and a similar trend was observed for the following treatment years. Table 1. Efficacy of Etanercept over the 5-year study period No of ETN receiversACRpediClinical Remission