AB0074 The effect of physical exercise in the cytokines levels in patients with systemic lupus erythematosus

Background The literature shows that acute exercise increases IL-6 [1,2] and IL-10 [3,4] and TNF-a [5,6] serum levels in healthy subjects and can worse the inflammatory response in patients with diabetes mellitus type I, cystic fibrosis and obstructive pulmonary disease [7]. Some studies showed resting SLE patients have higher levels of IL-6 [8,9] and IL-10 [8,10] compared to healthy controls. Although being established in the literature that SLE patients have benefits with the aerobic training [11] mainly related to cardiovascular risk factors, there is no study evaluating the effect of acute exercise on the cytokines levels in SLE patients what could cause some concerning about the risk of worsening inflammatory cytokines Objectives To assess the levels of IL-10, IL-6 and TNF-a at baseline and after acute exercise in SLE patients Methods Thirty female SLE patients (≥4 ACR criteria) with inactive or mild disease activity, and 30 age-and gender-matched healthy controls were included. At baseline and soon after the ergospirometric test 10 ml of peripheral blood were collected for IL-10, IL-6 and TNF-a measurement by ELISA technique (R&D Systems, Inc.-Minneapolis, USA). The disease activity was evaluated by SLEDAI. The Student’s t-tests and Mann-Whitney test were used for intra and inter-group comparisons. P values