THU0387 Relationship between patterns of clinical presentation uveitis and final immunologic diagnosis

Background In our multidisciplinary uveitis unit, coordinated by ophthalmologists and rheumatologists, a predefined set of 12 clinical patterns of uveitis presentation is used to help diagnose since 1992. The routinely use of these clinical patterns leads to a decrease in the number of diagnostic test to confirm the final diagnosis. Objectives To analyse the association between these clinical patterns and the final immunologic diagnosis and its discriminative value. Methods A prospective cohort study was performed. The study was approved by the ethic committee of our hospital. All patients attended in our multidisciplinary uveitis unit from January 1992 to December 2009 who were diagnosed with uveitis were selected. In all of them the following data were collected: the clinical patterns of uveitis presentation, the initial diagnosis, the medical history, the diagnostic test results and the final diagnosis. The 12 clinical patterns of uveitis presentation are: a) anterior uveitis (AU) including 1) acute recurrent unilateral AU (ARUAU), 2) acute nonrecurrent unilateral AU (ANRUAU), 3) acute bilateral AU (ABAU), 4) chronic AU (CAU), 5) intermediate uveitis (IU); b) posterior uveitis as 6) unilateral chorioretinitis (UC), 7) bilateral chorioretinitis (BC), 8) retinal vasculitis (RV), 9) chorioretinitis panuveitis (CP), 10) vitritis panuveitis (VP), 11) retinal vasculitis panuveitis (RVP) and 12) exudative retinal detachment panuveitis (ERD). To measure the association between uveitis and immunologic diagnosis a correspondence analysis was performed with every pattern. According to the model coordinates, 3 different levels of association were established -mild, high and very high-, based on the distance and magnitude of the coordinates. The highest absolute number and the smallest distance, the strongest association. Results: Uveitis PatternMajor DiagnosisAssociation Acute recurrent unilateral AUSpondyloarthropatyMild Acute nonrecurrent unilateral AUOphthalmologic AUMild Acute bilateral AUIdiopathic AUMild Chronic AUJuvenile Idiopathic ArthritisMild Unilateral chorioretinitisToxoplasmosisHigh Bilateral chorioretinitisOphthalmological chorioretinitisHigh VasculitisIdiopathic retinal vasculitisHigh Intermediate uveítisIdiopathic Intermediate uveitisHigh Chorioretintis panuvelitisToxoplamosisMild Vitritis panuveitisIdiopathic panuveitisHigh Vasculitis panuveitisBehçetHigh Exudative retinal detachment panuveitisVogt-Koyanagi-HaradaVery high Our data show the centra