AB1087 Tuberculosis infections and chronic inflammatory rheumatisms

Background The incidence of tuberculosis among patients with systemic rheumatic diseases is much higher than in the general population. Reactivation of a latent tuberculosis is frequent, and is related to immunosuppression induced by the underlying disease, and of immunosuppressive therapy. Objectives To evaluate the risk of TB infection among Tunisian patients suffering from systemic disease and to determine the characteristics of. Methods A retrospective study of records of patients who developed TB infection during the evolution of a systemic disease. Results Among 742 patients suffering from rheumatoid arthritis, 68 patients from systemic lupus, and 365 from ankylosing spondylitis, four patients were selected. Patient 1Patient 2Patient3Patient4 Sexfemalefemalemalemale Age70565855 Systemic desaserheumatoid arthritissystemic lupusrheumatoid arthritisAnkylosing spondylitis Duration of the systemic disease07 years10 yearsconcomitant13 years medicationMethotrexate + corticosteroidsHydroxychloroquine + corticosteroidsNo medicationcorticosteroids TB infection sitespondylodiscitisLungs (miliary)pleurapleura Infection proofHistopathological examination + positive BK search in sputumPositive IDR + Chest CT scan appearanceHistopathological examinationPositive IDR and Quantiferon test evolutionFavorable (recovery)Favorable (recovery)Favorable (recovery)dead Conclusions The screening strategies for tuberculosis should be extended in all patients with systemic rheumatic diseases receiving glucocorticoids and/or immunosuppressive therapy. In tunisa, tuberculosis remains frequent despite the efforts of TB control. Disclosure of Interest None Declared