AB1232 Mean platelet volume in patients with familial mediterranean fever

Background Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease.There are very limited study in the literature about mean platelet volume (MPV) levels in FMF patients. Objectives We aimed to investigate levels of mean MPV during attack period and attack free periods in Familial Mediterranean fever (FMF) patients and to compare with healthy controls. Methods The study consisted of 16 FMF patients during an attack, 51 FMF patients in attack-free period and 75 healthy controls. Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Results At the end of the study statistical analyses showed that MPV was significantly lower in FMF patients both during attack and attack-free than in healthy controls (p=0.015, p=0.016); however, there was no difference among during attack and attack-free patients (p=0.279). All results were shown in Table 1. Table 1 Group of healthy controlsGroup of attack-freeGroup of during attachPβP$P£ n=75n=51n=16 r Sex (F/M, % )56/19 (75/25)38/13 (75/25)10/6 (63/37)0.7810.9980.781 Age (year)33±831±1131±110.7910.2200.294 platelet (×103/L)276±67283±70324±790.0740.0570.016 MPV (fL)8.3±0.837.9±0.947.7±1.060.2790.0160.015 hemoglobin (g/dl)14.1±1.0613.9±1.2714.0±1.450.9240.6570.735 WBC (±103/μL)8.4±1.87.8±2.09.8±2.70.0070.0140.077 CRP (mg/L)–3.2±2.021.2±21.90.0001–– ESR (mm/s)–8.4±6.420±120.0001–– Conclusions We found that the MPV levels were significantly lower in the FMF group than in healthy controls. Our results suggest that patients with FMF have not an increased platelet activation. It was conculed that the lower MPV levels were an expected result of secondary thrombocytosis in FMF patients. Disclosure of Interest None Declared