SAT0233 Characteristics of primary sjögren’s syndrome (PSS) patients with cryoglobulinemia in a large cohort of patients, and differences between hypergammaglobulinemic and cryoglobulinemic vasculitis in PSS

Background Vasculitis in primary Sjögren’s syndrome (pSS) may be related to cthe presence of cryoglobulins (cryos) or hypergammaglobulinemia. Cryos reflect a high grade of B-cell lymphoproliferation, possibly leading to malignant lymphoma. Objectives Patients with pSS with cryos with or without vasculitis, and pSS with hypergammaglobulinemic vasculitis (hypergammaV) were retrospectively compared in a large cohort of consecutive patients. Methods Clinical, laboratory and histopathologic data in 1170 patients with pSS (1118 females, and 52 males, age at diagnosis 51±14 years) were collected. Univariate analyses were performed. Results cryos were tested in 850/1170 patients (72.6%), and detected in 59/850 (6.9%). Cryos were significantly associated with male sex (p=0.02), purpura (p