THU0414 The Incidence and Presentation of Systemic Lupus Erythematosus (SLE) in UK Primary Care Using the UK Clinical Practice Research Datalink (CPRD)

Background The onset of SLE is often described as varied and insidious yet few studies have described the pattern of the onset of symptoms using primary care data. We used the CPRD to investigate the way in which SLE presents in UK primary care. Objectives To calculate the incidence of SLE in the CPRD population between 1/1/00 and 31/12/12; to describe the presentation of symptoms of SLE and to determine the time from the accumulation of up to five SLE symptoms to SLE diagnosis. Methods We identified incident cases of SLE using a previously described identification algorithm1. Kaplan-Meier failure curves were constructed looking back from SLE diagnosis to the recording of symptoms related to SLE (i.e. using the presence of symptoms as the failure). The equality of the failure curves were compared for age group (