AB0429 Clinical manifestations and their association with the immunological profile of primary sjögren’s syndrome

Objectives 1-Describe the frequency of the clinical manifestations. 2- Assess their association with the antibodies anti Ro/La, ANA, Rheumatoid Factor (RF) in patients with Primary Sjögren’s Syndrome (pSS). Methods It was analyzed the information from the GESSAR’s (Argentine Sjögren’s Syndrome Group of Study) database of patients diagnosed with pSS according to 2002 American-European criteria. Results Out of 334 patients, 96% were women, with a median age of 57 (riq: 45-66), a median age at time of diagnosis of 52 (riq: 39-61) and a median age at onset of the symptoms of 47 (riq: 34-57), 95.78% presented xerophthalmia, 93.37% xerostomia, 32.18% parotid gland enlargement, 68.29% arthralgias, 29.58% arthritis, 8.22% purpura, 15.76% Raynaud’s disease, 5.41% pulmonary parenchymal affection, 3.60% renal affection, 9.24% peripheral neuropathy, 16.46% anemia of chronic diseases, 13.13% leukopenia and 49.36% polyclonal hypergammaglobulinemia. Anti Ro/anti La + 242/322, ANA + 264/319, RF + 138/299. In univariate analysis anti Ro/La was significantly associated with age (OR 0.98 IC95% 0.96-0.99, p