AB0205 Vitamin d status and its relation with disease activity, disability, treatment schedule, mood and quality of life in polish rheumatoid arthritis patients

Background Vitamin D deficiency is common in Poland. Epidemiological data suggest that it may be a risk factor for development or aggravation of autoimmune diseases. Some authors reported an inverse relationship between serum vitamin D metabolites concentration and disease activity, disability, pain and quality of life in patients with arthritis. Objectives The aim of the study was to estimate the prevalence of vitamin D deficiency in rheumatoid arthritis (RA) patients in Poland and to assess the correlation between 25-hydroxyvitamin D (25(OH)D) serum concentration and disease activity, treatment schedule, disability, quality of life and mood disturbances. Methods 113 RA patients (101 women,12men, mean age 59) were included in the study. Detailed information on previous treatment and vitamin D supplementation have been collected. The patients completed Short Form 36 Health Survey (SF-36), HAQ disability index and Beck Depression Inventory. Serum 25(OH)D, calcium, phosphorus and creatinine concentration have been performed in all patients. Disease Activity Score (DAS28) was used to evaluate disease activity. Results 17 (15%) patients (early RA) received no RA treatment Other patients were on methotrexate(≥15 mg/week) monotherapy (22;19.5%), methotrexate combined with low doses of prednisone (43;38.1%) and prednisone alone (31; 27.4%). Vitamin D deficiency (