SP0051 Activated Immune Cells Enzymatically Oxidize Membrane Lipids on Activation

Several new families of bioactive lipids were identified that form through the enzymatic oxidation of membrane phospholipids in circulating innate immune cells and platelets. These comprise eicosanoids attached to phosphatidylethanolamine (PE) and phosphatidylcholine (PC) and are generated early following cell activation by pathophysiological agonists. They form via the coordinated action of receptors and enzymes. In this presentation, what is currently known regarding their structures, mechanisms of formation, cell biology, and signaling actions will be summarized. The lipids promote coagulation, but inhibit Toll-like receptor signailing, and modulate neutrophil antibacterial responses. Phospholipid oxidation by acutely activated immune cells is a controlled event, and a central role in regulating membrane biology and innate immune function during health and disease is proposed. Current studies are establishing their role in vascular disease and antiphospholipid syndrome. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.6243