FRI0561 The role of patient global disease activity score in the definition of acr/eular remission in very early ra - results from the nor-veac study

Background Failure to fulfill the patient global disease activity (PGA) score < 1 cm criterion in the 2010 ACR/EULAR remission criteria has been shown to be the major determinant of “near misses” of remission in established RA1. It is not known if this factor is of the same importance when RA patients are identified and treated at a very early stage. Objectives To investigate the fulfillment of the Boolean version of the 2010 ACR/EULAR remission criteria after 2 years in patients with RA in a very early arthritis clinic, and to determine the major reasons for failing to fulfill these criteria. Methods Patients with arthritis of 1 had evaluator’s global disease activity (EGA) ≤ 1; 25 of these 44 (56.8 %) were in SDAI remission. 13 patients who were not in ACR/EULAR Boolean remission fulfilled the PGA criterion. Conclusions Elevated PGA was the major reason for not being in remission after 2 years in patients with very early RA fulfilling 3 out of 4 of the Boolean remission criteria, and in the majority of these patients EGA was ≤ 1. Application of an index-based remission definition (SDAI) resulted in higher remission frequencies in patients with elevated PGA. References Studenic P, et al. Near misses for ACR/EULAR criteria for remission: effects of patient global assessment in Boolean and ind