AB0256 Risk factors associated with generalized bone loss in patients with rheumatoid arthritis: retrospective longitudinal study

Background Vertebral fractures are major cause of disability and impaired quality of life in elderly people. Low bone mineral density has been reported a major risk factor for vertebral fracture. In patients with rheumatoid arthritis, it have been suggested that an appropriate management of the disease and the quality of bone prevent vertebral fractures. However, there are limited data concerning risk factors for bone mineral density loss in patients with rheumatoid arthritis. Objectives To evaluate the risk factors for generalized bone mineral density loss in patients with rheumatoid arthritis. Methods In a longitudinal study, lumbar spine bone mineral density (BMD) was measured at baseline and after average 1.2 years. Data of RA disease activity, treatment agents towards RA and osteoporosis, dietary and physical status were collected. With univariate logistic regression analyses we tested baseline variables for association with BMD loss. Variables showing an association (p