Interleukin (IL)23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for IL22 but not IL21 in autoimmune experimental arthritis

Interleukin (IL)23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for IL22 but not IL21 in autoimmune experimental arthritis

Objective To unravel the role of interleukin 23 (IL23) in subgroup polarisation of IL17α and/or interferon [GAMMA] (IFN[GAMMA]) T cells in the prone autoimmune DBA-1 mice with and without collagen-induced arthritis.

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Bibliographische Detailangaben
Veröffentlicht in:Annals of the rheumatic diseases 2010-03, Vol.69 (Suppl 2), p.A69
Hauptverfasser: Mus, A M C, Cornelissen, F, Asmawidjaja, P S, van Hamburg, J P, Boon, L, Hendriks, R W, Lubberts, E
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis
Cytokines
Lymphocytes
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Zusammenfassung:Objective To unravel the role of interleukin 23 (IL23) in subgroup polarisation of IL17α and/or interferon [GAMMA] (IFN[GAMMA]) T cells in the prone autoimmune DBA-1 mice with and without collagen-induced arthritis.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2010.129668j