Upon contact with stimulated T cells, expression of peptidylarginine deiminase 2 and 4 is upregulated in human monocytes

The expression of PADs was time-dependent as substantiated by the kinetics of PADI mRNA expression which revealed that after 4 h of contact PADI mRNAs were increased but declined rapidly to levels below baseline after 12 h of co-culture, whereas the production of PAD2 and PAD4 enzymes increased at 24 and 48 h of culture.