Treatment of collagen-induced arthritis with lentiviral BiP improves clinical parameters of disease

Treatment of collagen-induced arthritis with lentiviral BiP improves clinical parameters of disease

Lenti mBiP significantly reduced the mean number of arthritic paws in treated mice (2.6±0.3 vs 1.5±0.4 in control vs Lenti mBiP treated animals, p>0.05) and demonstrated a trend towards reductions in clinical (6.1±0.6 in control vs 3.7±1.2 in Lenti mBiP-treated animals) and histological score...

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Veröffentlicht in:Annals of the rheumatic diseases 2010-03, Vol.69 (Suppl 2), p.A56-A57
Hauptverfasser: Shields, A M, Wooley, P H, Thompson, S J, Klavinskis, L S, Panayi, G S, Antoniou, M, Corrigall, V M
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Sprache:eng
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Arthritis
Gene therapy
Proteins
Rodents
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container_end_page A57
container_issue Suppl 2
container_start_page A56
container_title Annals of the rheumatic diseases
container_volume 69
creator Shields, A M
Wooley, P H
Thompson, S J
Klavinskis, L S
Panayi, G S
Antoniou, M
Corrigall, V M
description Lenti mBiP significantly reduced the mean number of arthritic paws in treated mice (2.6±0.3 vs 1.5±0.4 in control vs Lenti mBiP treated animals, p>0.05) and demonstrated a trend towards reductions in clinical (6.1±0.6 in control vs 3.7±1.2 in Lenti mBiP-treated animals) and histological scores when mice were treated intraperitoneally with 107 infectious viral particles at arthritis onset.
doi_str_mv 10.1136/ard.2010.129643u
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subjects Arthritis
Gene therapy
Proteins
Rodents
title Treatment of collagen-induced arthritis with lentiviral BiP improves clinical parameters of disease
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