Treatment of collagen-induced arthritis with lentiviral BiP improves clinical parameters of disease

Treatment of collagen-induced arthritis with lentiviral BiP improves clinical parameters of disease

Lenti mBiP significantly reduced the mean number of arthritic paws in treated mice (2.6±0.3 vs 1.5±0.4 in control vs Lenti mBiP treated animals, p>0.05) and demonstrated a trend towards reductions in clinical (6.1±0.6 in control vs 3.7±1.2 in Lenti mBiP-treated animals) and histological score...

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Veröffentlicht in:Annals of the rheumatic diseases 2010-03, Vol.69 (Suppl 2), p.A56-A57
Hauptverfasser: Shields, A M, Wooley, P H, Thompson, S J, Klavinskis, L S, Panayi, G S, Antoniou, M, Corrigall, V M
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis
Gene therapy
Proteins
Rodents
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Zusammenfassung:Lenti mBiP significantly reduced the mean number of arthritic paws in treated mice (2.6±0.3 vs 1.5±0.4 in control vs Lenti mBiP treated animals, p>0.05) and demonstrated a trend towards reductions in clinical (6.1±0.6 in control vs 3.7±1.2 in Lenti mBiP-treated animals) and histological scores when mice were treated intraperitoneally with 107 infectious viral particles at arthritis onset.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2010.129643u