High doses of deferiprone may be associated with cerebellar syndrome

[...]this drug has shown great ability to cross the blood-brain barrier, and five patients treated with the usual dose for six months developed subclinical impairments of hearing and vision. 1 2 In our cases, the high dose may have had a direct toxic effect, or it might have caused excessive loss of other metals chelated by deferiprone (copper, zinc, aluminium, gallium) that are potentially important co-factors for enzyme activity. 3 These cases have led to the inclusion of neurological side effects in deferiprone's summary of product characteristics, and confirm that doses greater than 100 mg/kg/day should not be used.