Cholestatic hepatitis in association with celecoxib

None of these transaminase elevations was greater than eight times the upper limit of normal, in contrast to that found in the patient of O'Beirne and Cairns (about 41 times upper normal limit). [...]although we disagree with the view that this patient had cholestatic hepatitis on the basis of data quoted, the case does represent the first reported instance of severe hepatocellular liver dysfunction in association with celecoxib treatment.