Drug points: Acute renal failure due to rhabdomyolysis in presence of concurrent ciprofibrate and ibuprofen treatment

Drug points: Acute renal failure due to rhabdomyolysis in presence of concurrent ciprofibrate and ibuprofen treatment

Ibuprofen and ciprofibrate are heavily bound by protein (Sanofi Winthrop, technical brochure for ciprofibrate, 1992) 1 2 and contain propionic acid groups. 2 We postulate that ibuprofen displaced ciprofibrate, making what had been a safe dose for our patient become toxic, causing rhabdomyolysis and...

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Veröffentlicht in:BMJ 1997-05, Vol.314 (7094), p.1593-1593
Hauptverfasser: Ramachandran, S, Giles, P D
Format: Artikel
Sprache:eng
Schlagworte:
Cholesterol
Drug dosages
Kinases
Side effects
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Zusammenfassung:Ibuprofen and ciprofibrate are heavily bound by protein (Sanofi Winthrop, technical brochure for ciprofibrate, 1992) 1 2 and contain propionic acid groups. 2 We postulate that ibuprofen displaced ciprofibrate, making what had been a safe dose for our patient become toxic, causing rhabdomyolysis and renal failure.
ISSN:0959-8138
1468-5833
DOI:10.1136/bmj.314.7094.1593a