Is acute stress and plasminogen activator inhibitor polymorphism associated with acute ischemic stroke?

Highlights • Genetic risk factors play an important role in the etiology of vascular diseases. • PAI-1 is a crucial mediator of stress-induced hypercoagulability and thrombosis. • Mental and physical stress substantially decreases fibrinolytic activity. • The effect of PAI on the risk of stroke unde...

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Veröffentlicht in:	Clinical neurology and neurosurgery 2016-04, Vol.143, p.159-160
Hauptverfasser:	Kozak, Hasan Hüseyin, Uca, Ali Ulvi, Altaş, Mustafa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Disease Female Humans Magnetic Resonance Imaging Neurology Neurosurgery Plasminogen Activator Inhibitor 1 - genetics Polymorphism, Genetic - genetics Stress Stress, Psychological - complications Stress, Psychological - diagnostic imaging Stress, Psychological - genetics Stroke Stroke - diagnostic imaging Stroke - etiology Stroke - genetics Thrombosis
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Beschreibung
Zusammenfassung:	Highlights • Genetic risk factors play an important role in the etiology of vascular diseases. • PAI-1 is a crucial mediator of stress-induced hypercoagulability and thrombosis. • Mental and physical stress substantially decreases fibrinolytic activity. • The effect of PAI on the risk of stroke under stressful conditions should be investigated.
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2015.11.015