VEGFR1 and VEGFR2 in lip carcinogenesis and its association with microvessel density

The aim of the present study was to determine the role of vascular endothelial growth factor receptors (VEGFR1 and VEGFR2) in lip carcinogenesis, to investigate correlations between these markers with microvessel density (MVD) and clinicopathological aspects. Medical records from 27 cases of actinic...

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Veröffentlicht in:	Tumor biology 2015-09, Vol.36 (9), p.7285-7292
Hauptverfasser:	Ariotti, Carla, Wagner, Vivian Petersen, Salvadori, Gabriela, Carrard, Vinicius Coelho, Martins, Marco Antônio Trevizani, Filho, Joao Julio da Cunha, Meurer, Luise, Martins, Manoela Domingues
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell growth Epithelial Cells - metabolism Epithelial Cells - pathology Female Gene Expression Regulation, Neoplastic Humans Lip Neoplasms - genetics Lip Neoplasms - pathology Male Microvessels - physiopathology Neovascularization, Pathologic - genetics Oral cancer Research Article Studies Vascular Endothelial Growth Factor Receptor-1 - biosynthesis Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-2 - biosynthesis Vascular Endothelial Growth Factor Receptor-2 - genetics
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Zusammenfassung:	The aim of the present study was to determine the role of vascular endothelial growth factor receptors (VEGFR1 and VEGFR2) in lip carcinogenesis, to investigate correlations between these markers with microvessel density (MVD) and clinicopathological aspects. Medical records from 27 cases of actinic cheilitis (AC) and 46 cases of lower lip squamous cell carcinoma (LLSCC) were analysed and submitted to immunohistochemistry. VEGFR1- and VEGFR2-immunostained sections were analysed based on percentage of positive epithelial and inflammatory cells, while CD31 was submitted to quantitative analysis to determine MVD. Different patterns of VGFR1 and VEGFR2 expression were observed between AC and LLSCC. VEGFR1 expression in epithelial and inflammatory cells and VEGFR2 expression in epithelial cells were higher in AC compared to LLSCC ( p
ISSN:	1010-4283 1423-0380
DOI:	10.1007/s13277-015-3454-7