Relationship of Argyrophilic Proteins of Nucleolal Organizer Regions in Ki-67^sup +^ Cells with Clinical and Morphological Parameters in Lung Adenocarcinoma

Issue Title: This issue is a translation of Byulleten' Eksperimental'noi Biologii i Meditsiny (Bulletin of Experimental Biology and Medicine) and Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Ninety-four lung adenocarcinoma samples obtained during surgeries were examined using a combination of immunohistochemical staining for Ki-67 antigen and silver nitrate staining for argyrophilic nucleolar organizer (Ag-NOR) proteins. In lung adenocarcinoma, we studied the correlation between the area of Ag-NOR proteins in Ki-67^sup +^ cells and clinical and morphological TNM parameters: maximum tumor diameter (T) and stage of the disease and tumor differentiation degree (N). Survival of patients with small area of Ag-NOR proteins in Ki-67^sup +^ cells was higher that in patients with great area of these proteins. The area of Ag-NOR proteins in Ki-67^sup +^ cells is an independent prognostic factor in lung adenocarcinoma. The area of Ag-NOR proteins in Ki-67^sup +^ cells correlates with clinical and morphological TNM parameters and survival of patients with lung adenocarcinoma.