Copy Number Variation in Donor KIR Genes and Motifs Titrates Natural Killer (NK) Cells' Functional Response to EBV Infections and Influences the Risk of Developing Post-Transplant Lymphoproliferative Disease (PTLD) after Allogeneic HCT

PBMNCs from KIR typed healthy volunteers were stimulated with EBV transformed target cells to enumerate NK cell response to EBV (degranulation) and/or IFNÎ³ production) as a function of KIR gene content and motifs' distribution using a multicolor flow cytometry based assay.

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB2-AB2
Hauptverfasser:	Faridi, Rehan M., PhD, Kemp, Taylor, BHSc, Dharmani, Poonam, PhD, Lewis, Victor, MD, Berka, Noureddine, PhD, Storek, Jan, MD, PhD, Khan, Faisal, PhD
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Sprache:	eng
Schlagworte:	Allergy and Immunology Genes T cell receptors
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description	PBMNCs from KIR typed healthy volunteers were stimulated with EBV transformed target cells to enumerate NK cell response to EBV (degranulation) and/or IFNÎ³ production) as a function of KIR gene content and motifs' distribution using a multicolor flow cytometry based assay.
doi_str_mv	10.1016/j.jaci.2015.12.006
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source	Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Allergy and Immunology Genes T cell receptors
title	Copy Number Variation in Donor KIR Genes and Motifs Titrates Natural Killer (NK) Cells' Functional Response to EBV Infections and Influences the Risk of Developing Post-Transplant Lymphoproliferative Disease (PTLD) after Allogeneic HCT
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