Copy Number Variation in Donor KIR Genes and Motifs Titrates Natural Killer (NK) Cells' Functional Response to EBV Infections and Influences the Risk of Developing Post-Transplant Lymphoproliferative Disease (PTLD) after Allogeneic HCT

Copy Number Variation in Donor KIR Genes and Motifs Titrates Natural Killer (NK) Cells' Functional Response to EBV Infections and Influences the Risk of Developing Post-Transplant Lymphoproliferative Disease (PTLD) after Allogeneic HCT

PBMNCs from KIR typed healthy volunteers were stimulated with EBV transformed target cells to enumerate NK cell response to EBV (degranulation) and/or IFNγ production) as a function of KIR gene content and motifs' distribution using a multicolor flow cytometry based assay.

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Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB2-AB2
Hauptverfasser: Faridi, Rehan M., PhD, Kemp, Taylor, BHSc, Dharmani, Poonam, PhD, Lewis, Victor, MD, Berka, Noureddine, PhD, Storek, Jan, MD, PhD, Khan, Faisal, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Genes
T cell receptors
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Zusammenfassung:PBMNCs from KIR typed healthy volunteers were stimulated with EBV transformed target cells to enumerate NK cell response to EBV (degranulation) and/or IFNγ production) as a function of KIR gene content and motifs' distribution using a multicolor flow cytometry based assay.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.006