The calcium paradox - what should we have to fear?

The calcium paradox - what should we have to fear?

The calcium paradox was first mentioned in 1966 by Zimmerman et al. Thereafter gained great interest from the scientific community due to the fact of the absence of calcium ions in heart muscle cells produce damage similar to ischemia-reperfusion. Although not all known mechanisms involved in cellul...

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Veröffentlicht in:Revista brasileira de cirurgia cardiovascular 2014-01, Vol.29 (2), p.249
Hauptverfasser: Oliveira, Marcos Aurélio Barboza de, Brandi, Antônio Carlos, Dos Santos, Carlos Alberto, Botelho, Paulo Henrique Husseni, Cortez, José Luís Lasso, Goissis, Gilberto, Braile, Domingo Marcolino
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphate - metabolism
Animals
Caffeine - adverse effects
Calcium - administration & dosage
Calcium - metabolism
Calcium Channel Blockers - pharmacology
Cardiology
Cell Membrane Permeability
Dinitrophenols - metabolism
Glycocalyx - metabolism
Heart Failure - etiology
Heart Injuries - etiology
Heart Injuries - metabolism
Heart Injuries - pathology
Heart surgery
Humans
Myocardial Reperfusion Injury - metabolism
Myocardium - metabolism
Myocytes, Cardiac - metabolism
Rats
Sodium - physiology
Time Factors
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Zusammenfassung:The calcium paradox was first mentioned in 1966 by Zimmerman et al. Thereafter gained great interest from the scientific community due to the fact of the absence of calcium ions in heart muscle cells produce damage similar to ischemia-reperfusion. Although not all known mechanisms involved in cellular injury in the calcium paradox intercellular connection maintained only by nexus seems to have a key role in cellular fragmentation. The addition of small concentrations of calcium, calcium channel blockers, and hyponatraemia hypothermia are important to prevent any cellular damage during reperfusion solutions with physiological concentration of calcium.
ISSN:0102-7638
1678-9741
DOI:10.5935/1678-9741.20140054