Trilostane treatment of 78 dogs with pituitary-dependent hyperadrenocorticism

The efficacy of trilostane in the treatment of canine pituitary-dependent hyperadrenocorticism (PDH) was evaluated in 78 dogs with the condition which were treated for up to three years. The drug appeared to be well tolerated by almost all the dogs, and only two developed clinical signs and biochemi...

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Veröffentlicht in:Veterinary record 2002-06, Vol.150 (26), p.799-804
Hauptverfasser: Neiger, R., Hurley, K. J., Ramsey, I., O'Connor, J., Mooney, C. T.
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Sprache:eng
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Zusammenfassung:The efficacy of trilostane in the treatment of canine pituitary-dependent hyperadrenocorticism (PDH) was evaluated in 78 dogs with the condition which were treated for up to three years. The drug appeared to be well tolerated by almost all the dogs, and only two developed clinical signs and biochemical evidence of hypoadrenocorticism. Polyuria and polydipsia completely resolved in 70 per cent of the dogs that had these problems, and skin changes resolved in 62 per cent of the dogs that had skin abnormalities. There was a significant reduction (P
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.150.26.799