2-Chlorotetrafluoroethanesulfinamide Induced Diastereoselective Three-Component Aminoallylation of Aldehydes

The diastereoselective three-component reaction of aldehydes, allyl bromide, and （S）-2-chlorotetrafluoroethancsulfinamide was achieved in the presence of zinc powder and titanium（IV） isopropoxide. Compared to （S）-tert-butanesulfinamide, the reaction used zinc powder instead of indium and better resu...

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Veröffentlicht in:	Chinese journal of chemistry 2011-12, Vol.29 (12), p.2722-2726
1. Verfasser:	刘丽娟刘金涛
Format:	Artikel
Sprache:	eng
Schlagworte:	2-chlorotetrafluoroethanesulfinamide allylation amines asymmetric synthesis chiral auxiliary 三分量三组分异丙醇烯丙基溴立体观察芳香醛诱导非对映选择性
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Beschreibung
Zusammenfassung:	The diastereoselective three-component reaction of aldehydes, allyl bromide, and （S）-2-chlorotetrafluoroethancsulfinamide was achieved in the presence of zinc powder and titanium（IV） isopropoxide. Compared to （S）-tert-butanesulfinamide, the reaction used zinc powder instead of indium and better results were obtained with aromatic aldehydes. Moreover, opposite stereoselectivity is observed.
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201100134