Synthesis of Fluoroalkylated Allylic-[beta]-hydroxyesters and Fluoroalkylated [beta],[gamma]-Epoxy Esters from Ethyl 3-Hydroxy-4-pentenoate
A sequential transformation of fluoroalkylated adducts obtained from ethyl 3-hydroxy-4-pentenoate with fluorinated iodides was reported. The dehydrohalogenation of adducts was favored to give fluoroalkylated unsaturated [beta]-hydroxy esters in the presence of triethylamine. And intramolecular SN2 r...
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| Veröffentlicht in: | Chinese journal of chemistry 2011-12, Vol.29 (12), p.2669 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A sequential transformation of fluoroalkylated adducts obtained from ethyl 3-hydroxy-4-pentenoate with fluorinated iodides was reported. The dehydrohalogenation of adducts was favored to give fluoroalkylated unsaturated [beta]-hydroxy esters in the presence of triethylamine. And intramolecular SN2 reaction products, fluoroalkylated [beta],[gamma]-epoxy esters, were obtained in 10% aqueous sodium carbonate solution. |
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| ISSN: | 1001-604X 1614-7065 |
| DOI: | 10.1002/cjoc.201180437 |