Modular Three-Component Organocatalytic Synthesis of 3,4-Disubstituted Pyrroles by a One-Pot Domino Reaction

Modular Three-Component Organocatalytic Synthesis of 3,4-Disubstituted Pyrroles by a One-Pot Domino Reaction

Pull the trigger! The use of (Z)‐β,β‐bromo‐nitroalkenes under enamine catalysis provides the 1,4‐Michael adduct intermediate, which upon treatment with the desired amine (R3NH2) triggers the domino reaction to provide the final 3,4‐disubstituted pyrrole derivatives.

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Veröffentlicht in:ChemCatChem 2012-07, Vol.4 (7), p.976-979
Hauptverfasser: Martín-Santos, Cecilia, Jarava-Barrera, Carlos, Parra, Alejandro, Esteban, Francisco, Navarro-Ranninger, Carmen, Alemán, José
Format: Artikel
Sprache:eng
Schlagworte:
cascade reactions
enamine
one pot reactions
organocatalysis
pyrroles
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Zusammenfassung:Pull the trigger! The use of (Z)‐β,β‐bromo‐nitroalkenes under enamine catalysis provides the 1,4‐Michael adduct intermediate, which upon treatment with the desired amine (R3NH2) triggers the domino reaction to provide the final 3,4‐disubstituted pyrrole derivatives.
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201200104