Facile Synthesis of Thioamides via P2S5-Mediated Beckmann Rearrangement of Oximes

A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also efficient for the preparation of primary thiobenzamide from benzaldoxime. This approach features simple‐operation, easy‐control and good to excellent yields. Facile P2S5‐mediated synthesis of secondary thioamides from ketoximes via Beckmann rearrangement in one step was reported, without an extra dehydrating and thiating agent. This approach was also available for preparation of primary thiobenzamide from benzaldoxime.