Isosteviol-amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One-pot Three-component Mannich Reactions

Isosteviol-amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three-component Mannich reaction with hydroxyacetone as donor molecule. Good yields （up to 98%） and excellent stereoselectivities （up to 97 ： 3 dr and 99% ee） were achieved in a short reaction time. In addition, syn- or anti-configurations of a-hydroxy-β-amino carbonyl compounds were obtained as main products with different chiral catalysts.