Allergen-Specific CD4+ T Cells in Human Asthma Have an Increased Capacity to Respond to Innate Type 2 Signals

Allergen-Specific CD4+ T Cells in Human Asthma Have an Increased Capacity to Respond to Innate Type 2 Signals

Allergen-specific CD4+ T cells in the BAL were analyzed by flow cytometry after staining with dust mite (Der p 1) or cat (Fel d 1)-specific class II tetramers and antibodies to innate type 2 cytokine receptors (IL-33R and IL-25R) and other Th2 surface markers (CRTH2 and CCR4).

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Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB2-AB2
Hauptverfasser: Ling, Morris F., MD, Islam, Sabina A., MD, Hamilos, Daniel L., MD, FAAAAI, Cho, Josalyn L., MD, Griffith, Jason W., MD, PhD, Harris, R. Scott, MD, Kwok, William W., PhD, Moon, James J., PhD, Medoff, Benjamin D., MD, Luster, Andrew D., MD, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Allergy and Immunology
Asthma
Cytokines
Lymphocytes
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Zusammenfassung:Allergen-specific CD4+ T cells in the BAL were analyzed by flow cytometry after staining with dust mite (Der p 1) or cat (Fel d 1)-specific class II tetramers and antibodies to innate type 2 cytokine receptors (IL-33R and IL-25R) and other Th2 surface markers (CRTH2 and CCR4).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.007