IL-2 Mediates Generalized Tfh Downregulation during Allergen-Specific Immunotherapy

IL-2 Mediates Generalized Tfh Downregulation during Allergen-Specific Immunotherapy

Elucidating the exact mechanism by which IL-2 is involved in CXCR5 down-modulation and to what extend Tfh cell mobility and functionality is affected could give new insights into the mechanisms by which AIT modulated antibody responses.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB95-AB95
Hauptverfasser: Schulten, Véronique M., PhD, Crotty, Shane, PhD, Sette, Alessandro, Dr. Biol. Sci, Peters, Bjoern, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Allergy and Immunology
Immunotherapy
T cell receptors
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Beschreibung
Zusammenfassung:Elucidating the exact mechanism by which IL-2 is involved in CXCR5 down-modulation and to what extend Tfh cell mobility and functionality is affected could give new insights into the mechanisms by which AIT modulated antibody responses.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.436