Transglutaminase 2 over-Expressed By Interaction of Mast Cells and Oligodendrocytes Induces Demyelination in the Experimental Autoimmune Encephalomyelitis

Transglutaminase 2 over-Expressed By Interaction of Mast Cells and Oligodendrocytes Induces Demyelination in the Experimental Autoimmune Encephalomyelitis

Results KO mice reduced EAE scores, demyelinated area, mast cell numbers, expression of surface markers (CD40/CD40L) in mast cells and death signaling molecules in mOLs, co-localization of mast cells and mOLs in thalamus of EAE, whereas WT mice increased all of them in thalamus.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB76-AB76
Hauptverfasser: Hong, Gwan Ui, Ahn, Young Min, MD, Ro, Jai Youl, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Autoimmune diseases
Histamine
Localization
Rodents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Results KO mice reduced EAE scores, demyelinated area, mast cell numbers, expression of surface markers (CD40/CD40L) in mast cells and death signaling molecules in mOLs, co-localization of mast cells and mOLs in thalamus of EAE, whereas WT mice increased all of them in thalamus.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.257