Proton Pump Inhibitors (PPIs) May Modulate More Than Just Reflux in Chronic Rhinosinusitis with Nasal Polyps

Proton Pump Inhibitors (PPIs) May Modulate More Than Just Reflux in Chronic Rhinosinusitis with Nasal Polyps

In vitro, 5 different PPIs and the competitive H+/K+-ATPase inhibitor SCH-28080 all significantly inhibited IL-13-induced eotaxin-3 release by airway epithelial cells.

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Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB285-AB285
Hauptverfasser: Min, Jin Young, MD, PhD, Kern, Robert C., MD, Ocampo, Christopher J., MD, PhD, Stevens, Whitney W., MD, PhD, Price, Caroline P.E, Thompson, Christopher F., MD, Homma, Tetsuya, MD, PhD, Conley, David B., MD, Shintani-Smith, Stephanie, MD, Huang, Julia H, Suh, Lydia, BSc, Norton, James E., MS, Hulse, Kathryn E., PhD, Kato, Atsushi, PhD, Schleimer, Robert P., PhD, Tan, Bruce K., MD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Biomarkers
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Zusammenfassung:In vitro, 5 different PPIs and the competitive H+/K+-ATPase inhibitor SCH-28080 all significantly inhibited IL-13-induced eotaxin-3 release by airway epithelial cells.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.1179