Constitutive KIT Activity and IL-6 Production in Mast Cells Alters Levels of Reactive Oxygen Species (ROS) and the Scavenger Protein DJ-1 in Mastocytosis

Constitutive KIT Activity and IL-6 Production in Mast Cells Alters Levels of Reactive Oxygen Species (ROS) and the Scavenger Protein DJ-1 in Mastocytosis

Rationale Mastocytosis is characterized by hyperproliferation of mast cells (MCs) which is mostly associated with activating mutations in KIT, the stem cell factor (SCF) receptor.

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Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB281-AB281
Hauptverfasser: Kim, Dokyun, PhD, Beaven, Michael A., PhD, Kulinski, Joseph, PhD, Desai, Avanti, MS, Cruse, Glenn, PhD, Prussin, Calman, MD, Komarow, Hirsh D., MD, Carter, Melody C., MD, Metcalfe, Dean D., MD, Olivera, Ana, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Disease
Mutation
Oxygen
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Zusammenfassung:Rationale Mastocytosis is characterized by hyperproliferation of mast cells (MCs) which is mostly associated with activating mutations in KIT, the stem cell factor (SCF) receptor.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.1168