Pharmacodynamic Effect of DX-2930 on Plasma Kallikrein in Hereditary Angioedema Patients
Rationale Hereditary angioedema (HAE) attacks result from uncontrolled contact system activation which generates a burst of plasma kallikrein (pKal) that cleaves high-molecular-weight kininogen (HMWK) to produce 2-chain HMWK and the edema-inducing peptide, bradykinin.
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB252-AB252 |
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| container_end_page | AB252 |
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| container_issue | 2 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 137 |
| creator | Davis-Lorton, Mark A., MD FAAAAI Busse, Paula J., MD FAAAAI Banerji, Aleena, MD Shennak, Mustafa Lumry, William R., MD FAAAAI Wedner, H. James, MD FAAAAI Jacobs, Joshua S., MD Baker, James W., MD FAAAAI Bernstein, Jonathan A., MD Lockey, Richard F., MD Li, H. Henry, MD PhD Craig, Timothy J Cicardi, Marco Riedl, Marc A., MD MS Al-Ghazawi, Ahmad Soo, Carolyn Iarrobino, Ryan Sexton, Daniel TenHoor, Christopher Faucette, Ryan Biedenkapp, Joseph C Chyung, Yung H Adelman, Burt |
| description | Rationale Hereditary angioedema (HAE) attacks result from uncontrolled contact system activation which generates a burst of plasma kallikrein (pKal) that cleaves high-molecular-weight kininogen (HMWK) to produce 2-chain HMWK and the edema-inducing peptide, bradykinin. |
| doi_str_mv | 10.1016/j.jaci.2015.12.908 |
| format | Article |
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| source | Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Allergy and Immunology Drug dosages Plasma |
| title | Pharmacodynamic Effect of DX-2930 on Plasma Kallikrein in Hereditary Angioedema Patients |
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