Pharmacodynamic Effect of DX-2930 on Plasma Kallikrein in Hereditary Angioedema Patients

Pharmacodynamic Effect of DX-2930 on Plasma Kallikrein in Hereditary Angioedema Patients

Rationale Hereditary angioedema (HAE) attacks result from uncontrolled contact system activation which generates a burst of plasma kallikrein (pKal) that cleaves high-molecular-weight kininogen (HMWK) to produce 2-chain HMWK and the edema-inducing peptide, bradykinin.

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Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB252-AB252
Hauptverfasser: Davis-Lorton, Mark A., MD FAAAAI, Busse, Paula J., MD FAAAAI, Banerji, Aleena, MD, Shennak, Mustafa, Lumry, William R., MD FAAAAI, Wedner, H. James, MD FAAAAI, Jacobs, Joshua S., MD, Baker, James W., MD FAAAAI, Bernstein, Jonathan A., MD, Lockey, Richard F., MD, Li, H. Henry, MD PhD, Craig, Timothy J, Cicardi, Marco, Riedl, Marc A., MD MS, Al-Ghazawi, Ahmad, Soo, Carolyn, Iarrobino, Ryan, Sexton, Daniel, TenHoor, Christopher, Faucette, Ryan, Biedenkapp, Joseph C, Chyung, Yung H, Adelman, Burt
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Drug dosages
Plasma
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Zusammenfassung:Rationale Hereditary angioedema (HAE) attacks result from uncontrolled contact system activation which generates a burst of plasma kallikrein (pKal) that cleaves high-molecular-weight kininogen (HMWK) to produce 2-chain HMWK and the edema-inducing peptide, bradykinin.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.908