SIRT1 Attenuates Nasal Polypogenesis By Suppressing Epithelial-to-Mesenchymal Transition

SIRT1 Attenuates Nasal Polypogenesis By Suppressing Epithelial-to-Mesenchymal Transition

SIRT1, a histone deacetylase, reportedly suppresses the transcriptional activity of HIF-1. [...]the authors hypothesized that SIRT1 attenuates nasal polyposis by inhibiting HIF-1-induced EMT.

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Veröffentlicht in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB198-AB198
Hauptverfasser: Shin, Hyun-Woo, Lee, Mingyu, Kim, Dae Woo, MD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Hypoxia
Rodents
Online-Zugang:Volltext
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Zusammenfassung:SIRT1, a histone deacetylase, reportedly suppresses the transcriptional activity of HIF-1. [...]the authors hypothesized that SIRT1 attenuates nasal polyposis by inhibiting HIF-1-induced EMT.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.776