Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3 H -pyrazolo[3,4- d ]pyrimidin-3-one

Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3 H -pyrazolo[3,4- d ]pyrimidin-3-one

Synthesis of new 1,2-dihydro-3 H -pyrazolo[3,4- d ] pyrimidin-3-ones 4–6 starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate ( 1 ) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chlo...

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Veröffentlicht in:Heterocyclic communications 2016-02, Vol.22 (1), p.49-53
Hauptverfasser: Ebrahimpour, Zahra, Shiri, Ali, Bakavoli, Mehdi, Seyedi, Seyed Mohammad, Bahreini, Masoumeh, Oroojalian, Fatemeh
Format: Artikel
Sprache:eng
Schlagworte:
Chemical synthesis
Microwaves
Pharmacology
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Zusammenfassung:Synthesis of new 1,2-dihydro-3 H -pyrazolo[3,4- d ] pyrimidin-3-ones 4–6 starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate ( 1 ) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chloramphenicol and streptomycin as reference drugs.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2015-0145