Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

I′m stuck on you: The development of a highly active and stable immobilized transaminase capable of operating in organic solvent has been applied to the synthesis of various amines including Januvia (sitagliptin).

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Bibliographische Detailangaben
Veröffentlicht in:ChemCatChem 2012-08, Vol.4 (8), p.1071-1074
Hauptverfasser: Truppo, Matthew D., Strotman, Hallena, Hughes, Gregory
Format: Artikel
Sprache:eng
Schlagworte:
chiral amine
enzyme
immobilized
transaminase
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Beschreibung
Zusammenfassung:I′m stuck on you: The development of a highly active and stable immobilized transaminase capable of operating in organic solvent has been applied to the synthesis of various amines including Januvia (sitagliptin).
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201200228