ChemInform Abstract: Copper‐Catalyzed Asymmetric Conjugate Addition of Dimethylzinc to Acyl‐N‐methylimidazole Michael Acceptors: A Powerful Synthetic Platform

ChemInform Abstract: Copper‐Catalyzed Asymmetric Conjugate Addition of Dimethylzinc to Acyl‐N‐methylimidazole Michael Acceptors: A Powerful Synthetic Platform

The enantioselective addition of dimethylzinc to α,β‐unsaturated ketones of type (I) in the presence of Cu(OTf)2 and the chiral NHC (IMD) as catalysts affords the corresponding 1,4‐adducts (III) in high regio‐ and enantioselectivities.

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Veröffentlicht in:ChemInform 2016-01, Vol.47 (5), p.no-no
Hauptverfasser: Drissi‐Amraoui, Sammy, Morin, Marie S. T., Crevisy, Christophe, Basle, Olivier, Marcia de Figueiredo, Renata, Mauduit, Marc, Campagne, Jean‐Marc
Format: Artikel
Sprache:eng
Schlagworte:
addition reactions
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
imidazole derivatives
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Zusammenfassung:The enantioselective addition of dimethylzinc to α,β‐unsaturated ketones of type (I) in the presence of Cu(OTf)2 and the chiral NHC (IMD) as catalysts affords the corresponding 1,4‐adducts (III) in high regio‐ and enantioselectivities.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201605024