Transition-Metal-Free Cross-Coupling Reactions by Single Electron Transfer (SET)
A facile, efficient, single‐step protocol for the synthesis of cinnoline derivatives by a transition‐metal‐free coupling between amino‐ and nitroaryl compounds by single electron transfer (SET) has been developed. Direct carbon–carbon bond formation was achieved from nonfunctionalized aromatic carbo...
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Veröffentlicht in: | European journal of organic chemistry 2014-01, Vol.2014 (2), p.311-314 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A facile, efficient, single‐step protocol for the synthesis of cinnoline derivatives by a transition‐metal‐free coupling between amino‐ and nitroaryl compounds by single electron transfer (SET) has been developed. Direct carbon–carbon bond formation was achieved from nonfunctionalized aromatic carbon atoms. A plausible mechanism has been proposed.
Direct carbon–carbon bond formation between nonfunctionalized carbon atoms (C–H) in the presence of KOtBu for the synthesis of cinnoline derivatives was achieved. |
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ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.201301246 |