Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery

Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery

Five CF3‐substituted 3‐azabicyclo[n.1.0]alkanes were synthesized by CuCl‐mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides with CF3CHN2. A mini‐library of CF3‐substituted bicyclic amines has been synthesized by using CF3CHN2.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of organic chemistry 2014-06, Vol.2014 (17), p.3592-3598
Hauptverfasser: Artamonov, Olexiy S., Slobodyanyuk, Evgeniy Y., Volochnyuk, Dmitriy M., Komarov, Igor V., Tolmachev, Andrey A., Mykhailiuk, Pavel K.
Format: Artikel
Sprache:eng
Schlagworte:
Drug discovery
Fluorine
Nitrogen heterocycles
Synthetic methods
Trifluoromethyldiazomethane
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Five CF3‐substituted 3‐azabicyclo[n.1.0]alkanes were synthesized by CuCl‐mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides with CF3CHN2. A mini‐library of CF3‐substituted bicyclic amines has been synthesized by using CF3CHN2.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201402158