Activity of the CIR-dental School, University of Turin, for patients at risk of MRONJ: a five-year hospital based analysis

The aim of the study was to describe the clinical activity of the medication-related osteonecrosis of the jaw (MRONJ) clinic, CIR-Dental School, University of Turin, in order to compare these data with the international literature. The clinical data of the patients referred to Dental School of Turin from 2009 to 2014 were reviewed in order to describe the prevalence and the incidence of MRONJ regarding gender, age, kind of disease, kind of medication and timing of the event from the beginning of the antiresorptive/antiangiogenetic therapy, site, type of therapy (surgical vs. non surgical) and actual condition. In 64 patients (68.82%), MRONJ occurred in the lower jaw, in 26 (27.96%) in the upper jaw and only in 3 patients (3.23%) involved both jaws; 76 patients (81.72%) were treated with surgery and only 17 (18.28%) were treated only with conservative therapy. After treatment, 73 subjects (78.49%) improved or recovered; the other patients worsened or died before an improvement of the MRONJ. Actually 53.76% are still alive.