Synergic effects of curcumin and polydatin on MG63-osteosarcoma cells proliferation are mediated through down-regulation of Survivin

Nutraceuticals agents are among the most promising chemoprevention and treatment options for the management of cancer. Curcumin (diferuloylmethane), commonly known as turmeric, is a polyphenol derived from the curcuma longa plant. Curcumin has been found to possess anticancer activities via its effect on a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. Polydatin is a phytoalexins, molecules produced by spermatophytes plants to protect germinal centers, fruits, and roots, by attack by fungi, bacteria or free radicals. Both these molecules have demonstrated anticancer activity in many types of preclinical models. Curcumin activity seems to be mediated through the inhibition of NF-κB and MAPK; while Polydatin acts as an antioxidant agent. In this work, the authors evaluated a combination schedule of curcumin and polydatin against MG63 (doxorubicin resistant) osteosarcoma cells. Cells viability has been evaluated through MTT assay and xCELLIgence system; they found a synergic effect of this two agent against MG63 proliferation.