In-Vitro and in-Vivo Anti-Inflammatory Activities of Salvia hispanica and Linum usitatissium Seeds in Swiss Albino Rats
Salvia hispanica called as Chia seeds family Lamiaceae and Linum usitatissium called as Flax seeds family Linaceae was evaluated for its invitro and invivo anti-anti inflammatory activities individually and combined in swiss albio rats. Phytochemical screening analysis of both seeds revealed the pre...
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| Veröffentlicht in: | Research journal of pharmacy and technology 2015-10, Vol.8 (10), p.1438-1444 |
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| creator | Vidyasabbani Ramesh, A Snehalatha Rahul, Bhanu Sriharitha Sanjayvarma Aparna |
| description | Salvia hispanica called as Chia seeds family Lamiaceae and Linum usitatissium called as Flax seeds family Linaceae was evaluated for its invitro and invivo anti-anti inflammatory activities individually and combined in swiss albio rats. Phytochemical screening analysis of both seeds revealed the presence of flavanoids. The Fourier Transform Infrared Spectrophotometer (FTIR) analysis of chia and flax seeds confirmed the presence of amide, alcohols, phenols, alkanes, carboxylic acids, aldehydes, ketones, alkenes, primary amines, aromatics, esters, ethers, alkyl halides and aliphatic amines compounds, which showed major peaks. In-vivo anti-inflammatory activity was done on Swiss albino rats (150–250 gms) at two different doses (100 and 200 mg/kg body weight) by using 1% histamine induced paw edema test. In-vitro anti-inflammatory test was done by proteindenaturation and the human red blood cell (HRBC) membrane stabilization method. Data were analyzed by oneway analysis of variance (ANOVA) followed by Dunnett's t-test and the test of significance P value |
| doi_str_mv | 10.5958/0974-360X.2015.00258.9 |
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Phytochemical screening analysis of both seeds revealed the presence of flavanoids. The Fourier Transform Infrared Spectrophotometer (FTIR) analysis of chia and flax seeds confirmed the presence of amide, alcohols, phenols, alkanes, carboxylic acids, aldehydes, ketones, alkenes, primary amines, aromatics, esters, ethers, alkyl halides and aliphatic amines compounds, which showed major peaks. In-vivo anti-inflammatory activity was done on Swiss albino rats (150–250 gms) at two different doses (100 and 200 mg/kg body weight) by using 1% histamine induced paw edema test. In-vitro anti-inflammatory test was done by proteindenaturation and the human red blood cell (HRBC) membrane stabilization method. Data were analyzed by oneway analysis of variance (ANOVA) followed by Dunnett's t-test and the test of significance P value <0.05 was considered as the minimum level of significance. The paw volumes and percentages of inhibition of inflammation with chia and flax and standard drugs are reported and were observed that the seeds of chia and flax combination showed Synergistic action of inhibition at two doses compared to individual seeds. The inhibition was the highest at 3 h at 200 mg/kg dose which was slightly lower than Indomethacin effect. In the study of membrane stabilization activity of chia and flax combination at concentration range of 100–200 μg/ml protected significantly in a concentration dependent manner the erythrocyte membrane against lysis induced by hypotonic solution. Acetylsalicylic acid in the concentration of 100 μg/ml used as standard also offered significant (p<0.001) protection of RBC's membrane against damaging effect induced by hypotonic solution. The present research concludes that seeds of Salvia hispanica and Linum usitatissium possess anti-inflammatory activity in dose dependant manner and also proved synergistic activity.</description><identifier>ISSN: 0974-3618</identifier><identifier>EISSN: 0974-360X</identifier><identifier>EISSN: 0974-306X</identifier><identifier>DOI: 10.5958/0974-360X.2015.00258.9</identifier><language>eng</language><publisher>Raipur: A & V Publications</publisher><subject>Anti-inflammatory ; Human red blood cell (HRBC) ; Indomethacin ; Membrane stabilization ; Phytochemical screening ; Protein-denaturation ; Salvia hispanica and Linum usitatissium</subject><ispartof>Research journal of pharmacy and technology, 2015-10, Vol.8 (10), p.1438-1444</ispartof><rights>Copyright A&V Publications Oct 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Vidyasabbani</creatorcontrib><creatorcontrib>Ramesh, A</creatorcontrib><creatorcontrib>Snehalatha</creatorcontrib><creatorcontrib>Rahul, Bhanu</creatorcontrib><creatorcontrib>Sriharitha</creatorcontrib><creatorcontrib>Sanjayvarma</creatorcontrib><creatorcontrib>Aparna</creatorcontrib><title>In-Vitro and in-Vivo Anti-Inflammatory Activities of Salvia hispanica and Linum usitatissium Seeds in Swiss Albino Rats</title><title>Research journal of pharmacy and technology</title><description>Salvia hispanica called as Chia seeds family Lamiaceae and Linum usitatissium called as Flax seeds family Linaceae was evaluated for its invitro and invivo anti-anti inflammatory activities individually and combined in swiss albio rats. Phytochemical screening analysis of both seeds revealed the presence of flavanoids. The Fourier Transform Infrared Spectrophotometer (FTIR) analysis of chia and flax seeds confirmed the presence of amide, alcohols, phenols, alkanes, carboxylic acids, aldehydes, ketones, alkenes, primary amines, aromatics, esters, ethers, alkyl halides and aliphatic amines compounds, which showed major peaks. In-vivo anti-inflammatory activity was done on Swiss albino rats (150–250 gms) at two different doses (100 and 200 mg/kg body weight) by using 1% histamine induced paw edema test. In-vitro anti-inflammatory test was done by proteindenaturation and the human red blood cell (HRBC) membrane stabilization method. Data were analyzed by oneway analysis of variance (ANOVA) followed by Dunnett's t-test and the test of significance P value <0.05 was considered as the minimum level of significance. The paw volumes and percentages of inhibition of inflammation with chia and flax and standard drugs are reported and were observed that the seeds of chia and flax combination showed Synergistic action of inhibition at two doses compared to individual seeds. The inhibition was the highest at 3 h at 200 mg/kg dose which was slightly lower than Indomethacin effect. In the study of membrane stabilization activity of chia and flax combination at concentration range of 100–200 μg/ml protected significantly in a concentration dependent manner the erythrocyte membrane against lysis induced by hypotonic solution. Acetylsalicylic acid in the concentration of 100 μg/ml used as standard also offered significant (p<0.001) protection of RBC's membrane against damaging effect induced by hypotonic solution. The present research concludes that seeds of Salvia hispanica and Linum usitatissium possess anti-inflammatory activity in dose dependant manner and also proved synergistic activity.</description><subject>Anti-inflammatory</subject><subject>Human red blood cell (HRBC)</subject><subject>Indomethacin</subject><subject>Membrane stabilization</subject><subject>Phytochemical screening</subject><subject>Protein-denaturation</subject><subject>Salvia hispanica and Linum usitatissium</subject><issn>0974-3618</issn><issn>0974-360X</issn><issn>0974-306X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNo9kN1KAzEQhRdRsGhfQQJeb53sJrvJZSn-FAqCVfEuZLcJTmmzNUlb-vZmW-3c5ExmzhdysuyOwohLLh5A1iwvK_gaFUD5CKDgYiQvssF5cHnWVFxnwxCWkKoSvGBikO2nLv_E6Dui3YJg3-w6MnYR86mzK71e69j5Axm3EXcY0QTSWTLXqx1q8o1hox22-mieoduuyTZg1BFDwNTMjVmERCXzfboh41WDriNvOobb7MrqVTDDv_Mm-3h6fJ-85LPX5-lkPMtbWlDINdTMAJO8aABs0hVbWCsL0I2tm6pt61KKRjLDjQVhgRZtzSsL6W9GtDWUN9n9ibvx3c_WhKiW3da79KSideLKomb9VnXaan0XgjdWbTyutT8oCqrPWfURqj5O1eesjjkrmYz8ZES3QO3O7H-7X26iEj0FqFSUlUkzxspfTfyDDA</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Vidyasabbani</creator><creator>Ramesh, A</creator><creator>Snehalatha</creator><creator>Rahul, Bhanu</creator><creator>Sriharitha</creator><creator>Sanjayvarma</creator><creator>Aparna</creator><general>A & V Publications</general><general>A&V Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20151001</creationdate><title>In-Vitro and in-Vivo Anti-Inflammatory Activities of Salvia hispanica and Linum usitatissium Seeds in Swiss Albino Rats</title><author>Vidyasabbani ; 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Phytochemical screening analysis of both seeds revealed the presence of flavanoids. The Fourier Transform Infrared Spectrophotometer (FTIR) analysis of chia and flax seeds confirmed the presence of amide, alcohols, phenols, alkanes, carboxylic acids, aldehydes, ketones, alkenes, primary amines, aromatics, esters, ethers, alkyl halides and aliphatic amines compounds, which showed major peaks. In-vivo anti-inflammatory activity was done on Swiss albino rats (150–250 gms) at two different doses (100 and 200 mg/kg body weight) by using 1% histamine induced paw edema test. In-vitro anti-inflammatory test was done by proteindenaturation and the human red blood cell (HRBC) membrane stabilization method. Data were analyzed by oneway analysis of variance (ANOVA) followed by Dunnett's t-test and the test of significance P value <0.05 was considered as the minimum level of significance. The paw volumes and percentages of inhibition of inflammation with chia and flax and standard drugs are reported and were observed that the seeds of chia and flax combination showed Synergistic action of inhibition at two doses compared to individual seeds. The inhibition was the highest at 3 h at 200 mg/kg dose which was slightly lower than Indomethacin effect. In the study of membrane stabilization activity of chia and flax combination at concentration range of 100–200 μg/ml protected significantly in a concentration dependent manner the erythrocyte membrane against lysis induced by hypotonic solution. Acetylsalicylic acid in the concentration of 100 μg/ml used as standard also offered significant (p<0.001) protection of RBC's membrane against damaging effect induced by hypotonic solution. The present research concludes that seeds of Salvia hispanica and Linum usitatissium possess anti-inflammatory activity in dose dependant manner and also proved synergistic activity.</abstract><cop>Raipur</cop><pub>A & V Publications</pub><doi>10.5958/0974-360X.2015.00258.9</doi><tpages>7</tpages></addata></record> |
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| subjects | Anti-inflammatory Human red blood cell (HRBC) Indomethacin Membrane stabilization Phytochemical screening Protein-denaturation Salvia hispanica and Linum usitatissium |
| title | In-Vitro and in-Vivo Anti-Inflammatory Activities of Salvia hispanica and Linum usitatissium Seeds in Swiss Albino Rats |
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