Improving the 18F-fluoromethylcholine (18F-FCH) radiochemical yield via optimising the azeotropic drying of non-carrier-added 18F-fluorine

18F‐Fluoromethylcholine (18F‐FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in PET/CT examination. Nevertheless, it has never been synthesised in Malaysia. We acknowledged the major problem with 18F‐FCH is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this technical note presents improved 18F‐FCH radiochemical yields after carrying out optimisation on azeotropic drying of non‐carrier‐added 18F‐Fluorine. This technical note presents improved 18F‐Fluoromethylcholine (18F‐FCH) radiochemical yields after conducting optimisation on the azeotropic drying of non‐carrier‐added (n.c.a) 18F‐Fluorine. With this optimised strategy, the 18F‐FCH radiochemical yield was found to have increase by onefold. It was observed that improvement made to the azeotropic drying of n.c.a 18F‐FCH did not affect the radiochemical purity of 18F‐FCH.